In 332 BC. e. Tyre
In those days, there was, in modern terms, the category of prestige on certain goods.
So spices imported from India and Ceylon, were more prestigious of the same goods from Asia Minor and the Mediterranean.
Caravans with spices coming from the Persian Gulf and the Red Sea through Arabia, and the Tigris and Euphrates, flocked to the Phoenician city of Tyre on the eastern Mediterranean coast, hence their exported by sea in all other towns of the Mediterranean.
In 332 BC.
e.
Tyre was captured by the troops of Alexander the Great.
After that, the spice trade center moved to Carthage and then in the middle of the II century BC.
e.
.